Health News

Night shifts may hamper DNA repair

The findings suggested that night shifts suppress the production of 'sleep hormone' melatonin.

Published: 27th June 2017 05:01 PM  |   Last Updated: 27th June 2017 05:01 PM   |  A+A-

Image for representational purpose only.

By IANS

NEW YORK: If you are working on night shifts regularly, chances are your body's ability to repair DNA damage may get hampered, suggest researchers led by one of Indian-origin.

The findings suggested that night shifts suppress the production of 'sleep hormone' melatonin.

It revealed that a night shift worker produced lower levels of a chemical by-product of active DNA tissue repair called 8-OH-dG in the urine than his day counterpart, leading cells to harbour higher levels of DNA damage.

This indicated a reduced capacity to repair cellular damage, the study said.

The key factor behind this observed difference was likely to be suppressed production of the 'sleep hormone' melatonin during day sleep relative to night sleep, the researchers said.

"Our results indicate that, relative to night sleep, reduced melatonin production among shift workers during night work is associated with significantly reduced urinary excretion of 8-OH-dG," said Parveen Bhatti from the Fred Hutchinson Cancer Research Centre in Washington.

"This likely reflects a reduced capacity to repair oxidative DNA damage due to insufficient levels of melatonin and may result in cells harbouring higher levels of DNA damage," he continued.

"If such effects are confirmed, melatonin supplementation should be explored as an intervention to reduce the occurrence of potentially carcinogenic DNA damage among shift workers," Bhatti added.

For the study, published online in the journal Occupational and Environmental Medicine, the team measured 8-OH-dG levels in the stored urine samples of 50 night shift workers, who exhibited the widest discrepancies in levels of circulating melatonin between night work and night sleep.

An analysis of the urine samples showed that melatonin levels were much lower when taken during a night shift than when taken during a normal night's sleep.

Stay up to date on all the latest Health news with The New Indian Express App. Download now
Get the news that matters from New Indian Express on WhatsApp. Click this link and hit 'Click to Subscribe'. Follow the instructions after that.

Comments

Disclaimer : We respect your thoughts and views! But we need to be judicious while moderating your comments. All the comments will be moderated by the newindianexpress.com editorial. Abstain from posting comments that are obscene, defamatory or inflammatory, and do not indulge in personal attacks. Try to avoid outside hyperlinks inside the comment. Help us delete comments that do not follow these guidelines.

The views expressed in comments published on newindianexpress.com are those of the comment writers alone. They do not represent the views or opinions of newindianexpress.com or its staff, nor do they represent the views or opinions of The New Indian Express Group, or any entity of, or affiliated with, The New Indian Express Group. newindianexpress.com reserves the right to take any or all comments down at any time.

Latest